Primary Immunodeficiencies

By Dr. Vishaal Bhat on Tuesday 22 December 2009 with 0 comments



Over 70 primary immunodeficiencies have been described, and specialist consultation/ extensive laboratory testing is required to confirm or even establish the diagnosis. They are usually inherited or congenital, so that there is usually a family history of similar problems and that 80% of the patients are < 20 years old. Owing to the X-linked inheritance of many syndromes, 70% of the patients are male. The syndromes can be classified based on which component of the immune system is deficient: B cells, T cells, phagocytic cells or complement components. Increased susceptibility to pyogenic infections is associated with X-linked agammaglobulinemia (B cell defect), hyperimmunoglobulin E syndrome and chronic granulomatous disease (phagocytic cell defects) and C3, C5, Factor I [C3b inactivator] and Factor D (complement control proteins) deficiencies.  

A history of any of these conditions would lower your threshold for prescribing prophylactic antibiotic treatment for dental work.



Periodontitis is a feature of leukocyte adhesion defect type t (phagocytic cell defect).

Category: Microbiology Notes

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