Sjogren’s syndrome

By Dr. Vishaal Bhat on Saturday 5 January 2008 with 0 comments



  • Autoimmune disease characterized by the progressive lymphocytic infiltration and destruction of exocrine glands, particularly the salivary and lacrimal glands

  • Clinical hallmarks are keratoconjunctivitis sicca, xerostomia, and rheumatoid arthritis; may also be assoc. with other autoimmune disesases e.g. SLE

  • 90% patients are female; average age at diagnosis is 50 yr.

  • Firm, diffuse, painless enlargement of the salivary glands, which is usually but not always bilateral, is the typical presentation

  • Histologic hallmark is a lymphocytic sialadenitis—lymphoid follicles may be presentThese patients are at increased risk for non-Hodgkins lymphoma

Category: Oral Pathology Notes

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